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KMID : 0361520010120020115
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Korean Journal of Psychopharmacology
2001 Volume.12 No. 2 p.115 ~ p.123
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Newer Antipsychotics : Serotonin and Glutamate Receptor Related Drugs
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김찬형/Chan Hyung Kim
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Abstract
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Several decades of research attempting to explain schizophrenia regarding dopamine hyperactivity hypothesis have produced disappointing results. New hypotheses focusing on serotonin-dopamine interactions and hypofunction of the NMDA glutamate
transmitter system have been emerging as potentially more promising concepts. The next generation of treatments for schizophrenia, whether they are based on dopamine, serotonin, or glutamate etc., should be effective on negative symptoms and
cognitive
deficits as well as positive symptoms. In this article, I review the brief overview of these hypotheses and new drugs based on the hypotheses.
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